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Degradation properties of polyglutamine-expanded human androgen receptor in transfected cells

✍ Scribed by Daniel A. Cullen; P.Nigel Leigh; Jean-Marc Gallo

Book ID
116766370
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
165 KB
Volume
357
Category
Article
ISSN
0304-3940

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## Abstract Expanded polyglutamine tracts cause neurodegeneration through a toxic gain‐of‐function mechanism. Generation of inclusions is a common feature of polyglutamine diseases and other protein misfolding disorders. Inclusion formation is likely to be a defensive response of the cell to the pr