Degradation products of chloramphenicol

✍ Scribed by I. K. Shih

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 235 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600600527

✦ Synopsis

Incubated aqueous solutions of chloramphenicol at various p H s (1-14) yielded detectable amounts of pnitrobenzaldehyde (an oxidation product) and arylamine (a reduction product). Identical degradation products were also found in certain dosage forms (creams and capsules), although they were not found in ophthalmic ointment.

Keyphrases 0 Chloramphenicol-degradation products determined 0 pNitrobenzaldehyde-determined as degradation product in chloramphenicol 0 Arylamine-determined as degradation product in chloramphenicol ( 1970).