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Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue

✍ Scribed by Reinstein, Eyal; Scheffner, Martin; Oren, Moshe; Ciechanover, Aaron; Schwartz, Alan


Book ID
110064301
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
216 KB
Volume
19
Category
Article
ISSN
0950-9232

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The E6 protein of cancer-associated human papillomavirus type 16 (HPV16) binds to cellular p53 and promotes its degradation through the ubiquitin pathway. In an attempt to identify the regions of E6 that could be targetted for functional inhibition, we generated monoclonal antibodies to the HPV16 E6