Degradation of polyurethane foams used in the mêcme breast implant
✍ Scribed by Benoit, Frank M.
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 758 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
✦ Synopsis
The release of toluene diisocyanate derivatives from polyurethane foam covers that were removed from the M@me breast implant was studied. The polyurethane foam covers as retrieved from the implants were contaminated on average with 2,4-and 2,6-toluene diamine (TDA), 2,4-and 2,6-toluene diisocyanate (TDI), and toluene isocyanate amine (TIA) at the 1086ppm level (combined TDA, TDI, and TIA). When cleaned foam was incubated in Ringer's solution at 37°C for periods ranging from 6-35 days, 4.6 ppm/day of TDA, TDI, and TIA (combined) was formed; the projected annual degradation rate of the foam under these conditions was estimated to be about 0.8%. When cleaned foam was incubated dry at 37"C, 1.5 ppm/day of TDA, TDI, and TIA (combined) was produced. Hence, the polyurethane foam covers used in the M@me breast implants are susceptible to both thermal and hydrolytic degradation under simulated physiological conditions.