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Degradation of poly(lactide-co-glycolide) (PLGA) and poly(l-lactide) (PLLA) by electron beam radiation

✍ Scribed by J.S.C. Loo; C.P. Ooi; F.Y.C. Boey


Book ID
108069379
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
307 KB
Volume
26
Category
Article
ISSN
0142-9612

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## Abstract The ability to undergo predictable and controlled degradation allows biopolymers to release prescribed dosages of drugs locally over a sustained period. However, the bulk or homogeneous degradation of some of these polymers like poly(L‐lactide) (PLLA) and poly(lactide‐__co__‐glycolide)

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People's Republic of China SYNOPSIS Polylactide (PLA) and poly (lactide-co-glycolide) (PLGA) were prepared by bulk ringopening polymerization of lactide or lactide/glycolide using stannous octoate as initiator. PLA and PLGA microspheres with an average diameter of 65-100 pm were prepared by a solven