๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Degradation of paclitaxel and related compounds in aqueous solutions I: Epimerization

โœ Scribed by Jiaher Tian; Valentino J. Stella

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
215 KB
Volume
97
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Degradation of paclitaxel and related co
Degradation of paclitaxel and related compounds in aqueous solutions III: Degradation under acidic pH conditions and overall kinetics
โœ Jiaher Tian; Valentino J. Stella ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB

Paclitaxel and related taxanes are complex molecules with numerous hydrolysable ester groups, possible epimerization at the 7-position, and possessing a strained oxetane ring, a possible site for acid-catalyzed cleavage. Presented here is the stability of paclitaxel, 10-deacetylbaccatin III, baccati

Degradation of paclitaxel and related co
Degradation of paclitaxel and related compounds in aqueous solutions II: Nonepimerization degradation under neutral to basic pH conditions
โœ Jiaher Tian; Valentino J. Stella ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 248 KB ๐Ÿ‘ 1 views

Paclitaxel and other taxanes have complex structures that include the presence of numerous hydrolytically sensitive ester groups. The present study attempts to make sense of the kinetics of the base catalyzed hydrolysis of various ester groups found in paclitaxel by also studying the hydrolysis of 7