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Degradation of DNA by metalloanthracyclines: Requirement for metal ions

โœ Scribed by Yitbarek H. Mariam; Gwendolyn P. Glover


Book ID
115759711
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
421 KB
Volume
136
Category
Article
ISSN
0006-291X

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The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical compon