Degradation kinetics and mechanism of aminocephalosporins in aqueous solution: Cefadroxil

✍ Scribed by Akira Tsuji; Emi Nakashima; Yoshiharu Deguchi; Kazunori Nishide; Takayoshi Shimizu; Sumio Horiuchi; Kiyoyasu Ishikawa; Tsukinaka Yamana

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 909 KB
• Volume: 70
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600701008

✦ Synopsis

as well as nonpolar systems. An effort is being made to obtain W without solubility data, with the possibility of finding a physicochemical basis for W and/or a group contribution method for estimating this solventsolute interaction term.

It is interesting to observe in Table 111 and in Figs. 1 and 5 that small (fractional to 1 or 2%) differences between 6162, the geometric mean, and W, the correct adhesive energy density, may cause large differences (25-75%) between ideal and real solubilities. It will challenge the investigator to measure and calculate energies within 5-50 cal/mole required for an independent measure of W for accurate estimation of solubilities. The prediction of solubility using W from group contributions would represent a step toward a better understanding of the behavior of drug molecules in polar and nonpolar solvent systems.

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