A study of the degradation kinetics of gemcitabine hydrochloride (2ะ-deoxy-2ะ,2ะ-difluorocytidine) in aqueous solution at pH 3.2 was conducted. The degradation of gemcitabine followed pseudo first-order kinetics, and rate constants were determined at four different temperatures. These rates were use
Degradation chemistry of gemcitabine hydrochloride, a new antitumor agent
โ Scribed by Sally L. Anliker; Michael S. McClure; Thomas C. Britton; Erwin A. Stephan; Steven R. Maple; Gary G. Cooke
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 330 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Gemcitabine, while a standard treatment of advanced pancreatic cancer (PaCa), alone is not very effective. New agents that are safe and effective are highly needed. Resveratrol is one such agent which is safe and multitargeted; and has been linked with suppression of survival, prolifera