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Definitive chromosomal location of theH-2complex by in situ hybridization to pachytene chromosomes

✍ Scribed by Eric Lader; Brian T. Clark; S. C. Jhanwar; R. S. K. Chaganti; Dorothea Bennett

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
366 KB
Volume
22
Category
Article
ISSN
0093-7711

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✦ Synopsis

Chromosome 17 of the mouse carries the H-2 complex and the T/t complex. An understanding of the organization of this region and an accurate genetic map of chromosome 17 would be of great value for both immunologists and developmental biologists. Until now the only maps available have been derived solely from recombinational studies using several translocations, an inherently inaccurate method. We have found the definitive location of the H-2 complex by the use of in situ hybridization. Our results show that both the T/t complex and the H-2 complex map to positions far more distal than the generally accepted map positions. This proves that recombination in Robertsonian chromosomes underestimates physical map distances on chromosome 17.

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