Definition of a solvent system for spherical crystallization of salbutamol sulfate by quasi-emulsion solvent diffusion (QESD) method

✍ Scribed by M. Nocent; L. Bertocchi; F. Espitalier; M. Baron; G. Couarraze

• Book ID: 102398987
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 200 KB
• Volume: 90
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.1112

✦ Synopsis

In this paper we describe how the spherical crystallization process by QESD method can be applied to a water-soluble drug, salbutamol sulfate. The type of solvent, antisolvent, and emulsi®er and the concentration of emulsi®er to be used for the production of spherical particles with a size range 80±500 mm are determined. Furthermore, the solvent/antisolvent ratio and the temperature difference between them (DT) are studied . It was observed that, in the case of salbutamol sulfate, the DT value has no in¯uence on the formation of spherical particles. A very large metastable zone of salbutamol sulfate in water could explain this phenomenon. Finally, the in¯uence of emulsi®er concentration and of maturation time on the size of spherical particles is studied. The results show that these two parameters must be ®xed to control the size of the recovered particles.