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Defining the Cause of Skewed X-Chromosome Inactivation in X-Linked Mental Retardation by Use of a Mouse Model

✍ Scribed by Mary R. Muers; Jacqueline A. Sharpe; David Garrick; Jacqueline Sloane-Stanley; Patrick M. Nolan; Terry Hacker; William G. Wood; Douglas R. Higgs; Richard J. Gibbons


Book ID
117855202
Publisher
American Society of Human Genetics
Year
2007
Tongue
English
Weight
958 KB
Volume
80
Category
Article
ISSN
0002-9297

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Non-skewed X-inactivation may cause ment
✍ Takahito Wada; Hideo Sugie; Yoshimitsu Fukushima; Shinji Saitoh πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 60 KB πŸ‘ 2 views

X-linked alpha-thalassemia/mental retardation syndrome (ATR-X) is a syndromic form of X-linked mental retardation. We investigated the X-inactivation status of nine female ATR-X carriers by methylation-specific PCR of the HUMARA gene. Six carriers demonstrated a skewed X-inactivation pattern (>90:10