## Abstract In an attempt to analyze mechanisms of immunity against tumor metastases, protective anti‐tumor immunity __in vivo__ was compared with cytotoxic T‐cell activity __in vitro__ in a well‐defined syngeneic tumor model system. The system consists of a chemically induced parental tumor cell l
✦ LIBER ✦
Deficient tumor-specific immunity in old mice: in vivo mediation by suppressor cells, and correction of the defect by interleukin 2 supplementation in vitro but not in vivo
✍ Scribed by Martine Bruley-Rosset; Béatrice Payelle
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 624 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0014-2980
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We have examined the anti-tumor effect in nude mice caused by human pancreatic cancer cells (AsPC-1) modified to secrete IL-2 or IL-4. Loss of tumorigenicity of cytokineproducing, but not wild-type, cells was observed despite their unaltered in vitro proliferation rates; and these anti-tumor effects