Deficient production of anti-red cell autoantibodies by mice with an X-linked B lymphocyte defect

Induction by anti-CD40 antibody or solub

Induction by anti-CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X-linked hyper IgM syndrome

✍ Anne Durandy; Claudine Schiff; Jean Yves Bonnefoy; Monique Forveille; Françoise 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 551 KB

## Abstract We studied the ability of B lymphocytes from patients with X‐linked hyper IgM syndrome (HIGM1) to be activated via the CD40 membrane receptor. HIGM1 is caused by a CD40 ligand gene mutation, leading to defective expression on the membrane of activated T lymphocytes. We found that trigge