Deficiency of pluripotent hemopoietic progenitor cells in myelodysplastic syndromes

✍ Scribed by Geissler, K. ;Hinterberger, W. ;J�ger, U. ;Bettelheim, P. ;Neumann, E. ;Haas, O. ;Ambros, P. ;Chott, A. ;Radaszkiewicz, T. ;Lechner, K.

• Publisher: Springer-Verlag
• Year: 1988
• Weight: 395 KB
• Volume: 57
• Category: Article
• ISSN: 1432-0584
• DOI: 10.1007/bf00320634

✦ Synopsis

Pluripotent (CFU-MIX), erythroid (BFU-E) and granulocyte/macrophage (CFU-GM) progenitor cells were examined in bone marrow (BM) from 23 patients with myelodysplastic syndromes (MDS). Patients were grouped according to the FAB classification: Refractory anemia (RA), n = 3; RA with ring sideroblasts (RARS), n = 3; RA with excess of blasts (RAEB), n = 8; RA with excess of blasts in transformation (RAEBt), n = 7; chronic myelomonocytic leukemia (CMML), n = 2. In FAB groups RA, RARS, RAEB and RAEBt CFU-GM concentrations were normal or decreased but both CMML-patients had increased CFU-GM values. Abnormal cluster growth was observed in 9 of 23 MDS-patients. BFU-E colony formation was subnormal in all cases. Mixed-colony assay values were at the lower limit of controls in one patient and decreased in the remaining 22 MDS-patients. A similar growth pattern of hemopoietic progenitor cells was observed in 19 patients with acute nonlymphocytic leukemia (ANLL), who were studied for comparison. These data suggest a quantitative or qualitative/functional defect of the pluripotent progenitor cell compartment as the major cause for the cytopenia in MDS-patients.