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Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms

✍ Scribed by Thiel, S; Steffensen, R; Christensen, I J; Ip, W K; Lau, Y L; Reason, I J M; Eiberg, H; Gadjeva, M; Ruseva, M; Jensenius, J C


Book ID
110037877
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
159 KB
Volume
8
Category
Article
ISSN
1466-4879

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Genetic influences on mannan-binding lec
✍ Grith L. Sorensen; Inge Petersen; Steffen Thiel; Mogens Fenger; Kaare Christense πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 158 KB

## Abstract The lectin pathway of the complement system is activated when Mannan‐binding lectin (MBL) in complex with MASP‐2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease. The present s