The age dependence of the oval cell response and bile duct carcinomas of male F344 rats exposed to a cyclic choline deficiency-ethionine (CDE) diet (2 weeks on, 1 week off ) supports the concept of loss of potential of liver stem cells to form cancers with aging. Livers of rats exposed at 3 weeks of
Deficiency of bile acid transport and synthesis in oval cells from carcinogen-fed rats
โ Scribed by Matthias Blumrich; Renate Pack; Franz Oesch; Prof. Dr. Ernst Petzinger; Pablo Steinberg
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 592 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
โฆ Synopsis
Oval cells are liver nonparenchymal epithelial cells most probably originating from the Hering canals or cells located near these canals in the periportal areas of the rat liver (1-3). They proliferate during hepatocarcinogenesis and chemically induced severe liver injury
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