Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome

Salivary gland B cell lymphoproliferativ

Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas

✍ Valli De Re; Salvatore De Vita; Daniela Gasparotto; Alessandra Marzotto; Antonin 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB 👁 1 views

Sjögren's syndrome (SS) represents a pathological model of the evolution from polyclonal B lymphocyte activation to oligoclonal/monoclonal B cell expansion, which may culminate in the development of a malignant lymphoproliferative disease. The different phases of this process are usually marked by t