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Deficiency in nitric oxide bioactivity in epicardial coronary arteries of cigarette smokers

โœ Scribed by Kiyotaka Kugiyama; Hirofumi Yasue; Masamichi Ohgushi; Takeshi Motoyama; Hiroaki Kawano; Yoshito Inobe; Osamu Hirashima; Seigo Sugiyama


Book ID
118584502
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
742 KB
Volume
28
Category
Article
ISSN
1558-3597

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Nitric oxide (NO) synthesized by endothelial cell nitric oxide synthase (eNOS) elicits vasodilation of resistance-sized coronary microvessels. Since coronary blood flow increases during hypoxia, we tested the hypotheses that: (1) hypoxia results in increased blood flow through increased NO productio