✦ LIBER ✦

Deficiency in catalase activity correlates with the appearance of tumor phenotype in human keratinocytes

✍ Scribed by Thierry Rabilloud; Daniel Asselineau; Corinne Miquel; Regis Calvayrac; Michel Darmon; Monique Vuillaume

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 545 KB
Volume: 45
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910450529

No coin nor oath required. For personal study only.

✦ Synopsis

Biopsies isolated from various human stratified epitheliomas and cultures of the associated fibroblasts exhibit a breakdown in catalase activity (70 to 95%). We report here that primary human cultures of keratinocyter and various immortalized keratinocyte cell lines differ from one other in their catalase activity. Moreover, deficient catalase activity appears to be related to the intensity of tumor phenotype expression, Since catalase activity in cell lines transformed in vitro is not as weak as activity observed in cell lines isolated from tumors, catalase deficiency may follow the successive steps of tumor progression.

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