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Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease and Multiorgan Failure after Stem Cell Transplantation: A Multicenter, Randomized, Dose-Finding Trial

✍ Scribed by Paul G. Richardson; Robert J. Soiffer; Joseph H. Antin; Hajime Uno; Zhezhen Jin; Joanne Kurtzberg; Paul L. Martin; Gideon Steinbach; Karen F. Murray; Georgia B. Vogelsang; Allen R. Chen; Amrita Krishnan; Nancy A. Kernan; David E. Avigan; Thomas R. Spitzer; Howard M. Shulman; Donald N. Di Salvo; Carolyn Revta; Diane Warren; Parisa Momtaz; Gary Bradwin; L.J. Wei; Massimo Iacobelli; George B. McDonald; Eva C. Guinan

Book ID
116281756
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
612 KB
Volume
16
Category
Article
ISSN
1083-8791

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✍ Ohashi, Kazuteru; Tanabe, Juichi; Watanabe, Reiko; Tanaka, Takeshi; Sakamaki, Hi πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 95 KB πŸ‘ 2 views

## Hepatic veno-occlusive disease (VOD) is a common transplant-related complication of stem cell transplantation. There is no safe and proven therapy for established VOD, and attempts have focused on its prevention. Limited studies have suggested that prophylactic use of ursodeoxycholic acid (UDCA)