Deferiprone, an oral iron chelator, ameliorates experimental colitis and gastric ulceration in rats
✍ Scribed by Jacob Ablin; Oded Shalev; Elimelech Okon; Fanny Karmeli; Dr. Daniel Rachmilewitz
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 904 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1078-0998
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✦ Synopsis
lron is pivotal in producing tissue-damaging reactive oxygen metabolites. Our aim is to determine the antiinflammatory activity of deferiprone, an oral iron chelator, in experimental colitis and gastritis. Colitis was induced by intraceccal administration of 2 ml 5% acetic acid or by intracolonic administration of 0.1 ml3% iodoacetamide, with or without cotreatment with deferiprone. Gastritis was induced by intragastric administration of ethanol or hydrochloric acid (HCI) and by subcutaneous injection of indomethacin, with and without deferiprone. Rats were killed 24 hours after acetic acid and iodoacetamide, 30 minutes after .ethanol, one hour after HCl, and three hours after indomethacin administration. The colon or stomach was isolated, macroscopic damage was measured, and mucosal samples were obtained for determination of eicosanoid generation, myeloperoxidase (MPO), and nitric oxide synthase -age to the bowel (3). Superoxide dismutase (SOD) and shown to be protective against experimental colitis in rats (9,lO) and in uncontrolled trials in IBD (11,12),