Deferasirox in pyruvate kinase deficiency
β Scribed by Dries Deeren
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 40 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0939-5555
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π SIMILAR VOLUMES
Erythrocyte pyruvate kinase (PK) from 5 patients with cogenital non-spherocytic hemolytic and erythrocyte PK deficiency have been studied by immunological methods and electrofucusing. L type immunologically related PK was titrated in crude hemolysate with anti human liver L type PK rabbit serum and
The defective PK variant of a patient with a severe form of hemolytic anemia was characterized by its inability to undergo a normal 'proteolytic maturation.' In obligatory heterozygotes it could be proved that red cells contained different PK species, some of them sensitive and the others partially