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Defects in Sensory and Autonomic Ganglia and Absence of Locus Coeruleus in Mice Deficient for the Homeobox Gene Phox2a

✍ Scribed by Xavier Morin; Harold Cremer; Marie-Rose Hirsch; Raj P. Kapur; Christo Goridis; Jean-François Brunet


Book ID
117607685
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
831 KB
Volume
18
Category
Article
ISSN
0896-6273

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CD22 is an inhibitory coreceptor for B cell receptor (BCR) signaling. The inhibition is most likely mediated by activation of SHP-1. We found that SLP65/BLNK reaches maximal tyrosine-phosphorylation at earlier time points in CD22(-/-) than in wild type B cells upon BCR cross-linking, suggesting that