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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

โœ Scribed by L.J. Holsinger; I.A. Graef; W. Swat; T. Chi; D.M. Bautista; L. Davidson; R.S. Lewis; F.W. Alt; G.R. Crabtree


Book ID
114321143
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
192 KB
Volume
8
Category
Article
ISSN
0960-9822

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Defects in actin-cap formation in Vav-de
โœ L.J. Holsinger; I.A. Graef; W. Swat; T. Chi; D.M. Bautista; L. Davidson; R.S. Le ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 192 KB

## Background: Antigen-receptor interactions on lymphocytes result in local clustering of actin, receptors and signaling molecules into an asymmetric membrane structure termed a cap. although actin polymerization is known to be required, the mechanisms underlying cap formation are unclear. we have