Defective transient endogenous spleen colony formation in S1/S1d mice

✍ Scribed by W. Wiktor-Jedrzejczak; A. Ahmed; S. J. Sharkis; A. McKee; K. W. Sell

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 357 KB
• Volume: 99
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040990105

✦ Synopsis

Abstract

WCB6F~1~ mice of the genotype S1/S1^d^ did not form transient 5‐day endogenous spleen colonies following midlethal irradiation, either spontaneously or in response to postirradiation bleeding. Their hematologically normal (+/+) littermates produced colonies equivalent in number and morphologic type to a normal strain (D2B6F~1~), as evaluated by both macroscopic and microscopic criteria. Bone marrow cells from S1/S1^d^ mice, when transplanted into lethally irradiated +/+ mice, were able to generate equivalent numbers of transient endogenous spleen colonies (TE‐CFUs), as compared to that obtained when syngeneic +/+ marrow cells were injected into lethally irradiated +/+ recipients. A defective growth of an early class of hematopoietic progenitor cells, resulting in the clinical course of the S1/S1^d^ anemia is suggested and confirms previous reports on the microenvironmental nature of this abnormality.