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Defective Retrovirus Insertion Activates c-Ha-ras Proto-oncogene in an MNU-Induced Rat Mammary Carcinoma

✍ Scribed by Tapan K. Bera; Tetsuya Tsukamoto; Dibyendu K. Panda; Tony Huang; Raphael C. Guzman; Soo-In Hwang; Satyabrata Nandi

Book ID: 115582461
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 627 KB
Volume: 248
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1998.9059

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## Abstract Spontaneously immortalized human mammary epithelial cells MCF‐IOA were transfected with an activated c‐Ha‐ras oncogene. Transfected cells (MCF‐IOT) acquire a malignant pheno‐type, as already reported. Studies of l‐2′‐deoxyuridine incorporation in cultures given graded doses of hydrocort