✦ LIBER ✦

Defective response to interferons in cells transfected with the hepatitis B virus genome

✍ Scribed by Morikazu Onji; Andrew M. L. Lever; Izumu Saito; Professor Howard C. Thomas

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 451 KB
Volume: 9
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840090115

No coin nor oath required. For personal study only.

✦ Synopsis

The interferon responsiveness of two cell lines transfected with the hepatitis B virus genome was investigated. A cosmid vector containing multiple copies of the hepatitis B virus genome was transfected into FLS-1 cells; it reduced their sensitivity to interferons as measured by inhibition of the cytopathic effect of Sindbis virus challenge. Similar vectors transfected into HeLa cells reduced their sensitivity to interferon as measured by production of /32-microglobulin.

This resistance to interferon in hepatitis B virustransfected cells may be a trans-acting phenomenon related to nucleotide homology between hepatitis B virus DNA and sequences regulating the interferon-induced antiviral system. Alternatively, other mechanisms involving transcription or translation products of hepatitis B virus may be responsible.

Hepatitis B virus-induced cellular resistance to the action of interferon may be important in maintaining the chronic carrier state.

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