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Defective regulation of leukemic hematopoiesis in chronic myeloid leukemia

✍ Scribed by C Eaves; J Cashman; A Eaves

Book ID
114119522
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
143 KB
Volume
22
Category
Article
ISSN
0145-2126

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## Abstract Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the __bcr‐abl__ oncogene. The BCR‐ABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell func