Defective phagocytosis confined toStaphylococcus aureusin a female infant with recurrent infections
✍ Scribed by Setsuko Ito; Haruki Mikawa; Takao Hirao; Takami Yoshida; Rokuro Okuda
- Book ID
- 104776941
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 740 KB
- Volume
- 133
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
Defective chemotaxis and phagocytosis of
Staphylococcus aureus was identified in a female infant with marked hepatosplenomegaly and recurrent infections. Neutrophil mobilization from the marrow and marginal pool; random mobility; phagocytosis of yeast particles, latex beads and carbon particles; phagocytosis and intracellular killing capacity of Streptococcus pyogenes and E. coli; and NBT dye reduction were normal. Infiltration of neutrophils was depressed in the skin window test. The complement system and cellular immunity were intact. The patient also had a persistent EB virus infection.
Defective phagocytosis limited to Staphylococcus aureus seems to be caused by an intrinsic cellular defect, such as congenital defect in neutrophil receptors for Staphylococcus aureus.