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Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis

✍ Scribed by Mercedes Pérez-Carreras; Pilar Del Hoyo; Miguel A. Martı́n; Juan C. Rubio; Ana Martı́n; Gregorio Castellano; Francisco Colina; Joaquı́n Arenas; José A. Solis-Herruzo

Book ID
118686884
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
936 KB
Volume
38
Category
Article
ISSN
0270-9139

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Defective hepatic mitochondrial respirat
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
✍ Mercedes Pérez-Carreras; Pilar Del Hoyo; Miguel A. Martín; Juan C. Rubio; Ana Ma 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 994 KB

Mitochondrial dysfunction might play a central role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The aims of this study were to evaluate whether free fatty acid (FFA) transport into the mitochondria or the activity of mitochondria respiratory chain (MRC) complexes are impaired in NASH

Hepatic cytochrome P450 2E1 is increased
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Nonalcoholic steatohepatitis (NASH) has multiple etiologic associations, but the pathogenesis is poorly understood. Cytochrome P450 (CYP) 2E1 is induced in the liver of patients who drink alcohol to excess and is important in the pathogenesis of alcoholic liver disease (ALD). We have previously show