Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
✍ Scribed by Korthäuer, Ulf; Graf, Daniel; Mages, Hans W.; Brière, Francine; Padayachee, Munoreedevi; Malcolm, Sue; Ugazio, Alberto G.; Notarangelo, Luigi D.; Levinsky, Roland J.; Kroczek, Richard A.
- Book ID
- 109783210
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 361 KB
- Volume
- 361
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/361539a0
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## Abstract We studied the ability of B lymphocytes from patients with X‐linked hyper IgM syndrome (HIGM1) to be activated via the CD40 membrane receptor. HIGM1 is caused by a CD40 ligand gene mutation, leading to defective expression on the membrane of activated T lymphocytes. We found that trigge
The pattern of X-chromosome inactivation was analyzed, by means of two different DNA probes (pSPT-PGK and M27 beta), in several cell lineages derived from females belonging to a pedigree with X-linked immunodeficiency with hyper-IgM (HIGM1). Non-random X-chromosome inactivation was demonstrated in T