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Defective Cell Cycle Checkpoint Functions in Melanoma Are Associated with Altered Patterns of Gene Expression

✍ Scribed by Kaufmann, William K; Nevis, Kathleen R; Qu, Pingping; Ibrahim, Joseph G; Zhou, Tong; Zhou, Yingchun; Simpson, Dennis A; Helms-Deaton, Jennifer; Cordeiro-Stone, Marila; Moore, Dominic T

Book ID: 110050005
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 333 KB
Volume: 128
Category: Article
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5700935

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## Abstract The tightly controlled network of cell cycle genes consists of a core of cyclin dependent kinases (CDKs) that are activated by periodically expressed cyclins. The activity of the cyclin‐CDK complexes is regulated by cyclin dependent kinase inhibitors (CDKIs) and multiple signal transduc