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Defective B-1 Cell Development and Impaired Immunity against Angiostrongylus cantonensis in IL-5Rα-Deficient Mice

✍ Scribed by Toshimi Yoshida; Koichi Ikuta; Hiroko Sugaya; Kazushige Maki; Mineo Takagi; Hiroko Kanazawa; Shinji Sunaga; Tatsuo Kinashi; Kentarou Yoshimura; Jun-ichi Miyazaki; Satoshi Takaki; Kiyoshi Takatsu

Book ID
117722788
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
223 KB
Volume
4
Category
Article
ISSN
1074-7613

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## Abstract The cytokine IL‐7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL‐7 receptor α‐deficient mice. We demonstrate that the IL‐7 receptor becomes progressively more important with age.