✦ LIBER ✦
Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features
✍ Scribed by Kamphuisen, Pieter W.; Haan, Joost; Rosekrans, Peter C.M.; Van Der Meer, Felix J.M.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 17 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
We report a 71-year-old man who developed deep-vein thrombosis after major surgery. Coumarin skin necrosis developed after starting oral anticoagulant therapy. An inhibitor to factor V (61 Bethesda units) with lupus-like features was found as well as a low protein C level. The occurrence of these very rare findings indicates that despite profound procoagulant inhibition (factor V inhibition and anticoagulant therapy), hypercoagulation can occur. Am.