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Deep proteome and transcriptome mapping of a human cancer cell line

✍ Scribed by Nagaraj, Nagarjuna (author);Wisniewski, Jacek R. (author);Geiger, Tamar (author);Cox, Juergen (author);Kircher, Martin (author);Kelso, Janet (author);Pääbo, Svante (author);Mann, Matthias (author)


Book ID
119980304
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
983 KB
Volume
7
Category
Article
ISSN
1744-4292

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## Abstract In order to understand the molecular mechanisms of multidrug resistance (MDR) in ovarian cancer, we employed the proteomic approach of isobaric tags for relative and absolute quantification (iTRAQ), followed by LC‐MS/MS, using the cisplatin‐resistant COC1/DDP cell line and its parental