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Deep brain stimulation to treat hyperkinetic symptoms of cockayne syndrome

✍ Scribed by Matthew O. Hebb; Paula Gaudet; Ivar Mendez

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 85 KB
Volume: 21
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20665

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✦ Synopsis

Abstract

Cockayne syndrome manifests a spectrum of neurological dysfunction that includes medically intractable movement disorders. Deep brain stimulation has not been well studied in such rare neurodegenerative conditions. In this case, stimulation of the ventral intermediate nucleus of the thalamus was used to manage severe motor symptoms in a young man with Cockayne syndrome. There was a marked and progressive response to thalamic stimulation within weeks of surgery. These results suggest that patients with Cockayne syndrome should be considered for deep brain stimulation to treat refractory movement disorders. © 2005 Movement Disorder Society

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