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Deep brain stimulation: Neuropsychological and neuropsychiatric issues

✍ Scribed by Valerie Voon; Cynthia Kubu; Paul Krack; Jean-Luc Houeto; Alexander I. Tröster

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
161 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor, cognitive, neuropsychiatric, autonomic, and other nonmotor symptoms. The efficacy of deep brain stimulation (DBS) for the motor symptoms of advanced PD is well established. However, the effects of DBS on the cognitive and neuropsychiatric symptoms are less clear. The neuropsychiatric aspects of DBS for PD have recently been of considerable clinical and pathophysiological interest. As a companion to the preoperative and postoperative sections of the DBS consensus articles, this article reviews the published lit-erature on the cognitive and neuropsychiatric aspects of DBS for PD. The majority of the observed neuropsychiatric symptoms are transient, treatable, and potentially preventable. Outcome studies, methodological issues, pathophysiology, and preoperative and postoperative management of the cognitive and neuropsychiatric aspects and complications of DBS for PD are discussed.

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