Deep brain stimulation in Huntington's disease
β Scribed by Raphael M. Bonelli; Andreas Gruber
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 46 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0885-3185
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## Abstract Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is being evaluated as a potential new therapy for patients with Huntington's disease (HD). In addition to skeletal movement disorders, HD patients have difficulty initiating voluntary saccades and have difficulty in supp
## Abstract The silent period evoked by transcranial (TCS) and nerve stimulation was studied in the hand muscles in 13 patients with Huntington's disease and in 11 normal subjects. The duration of the silent period after TCS was longer in patients and correlated significantly with the severity of c
## Abstract Eight patients with advanced PD received a unilateral STN DBS. The UPDRS III __off__ drugβon DBS was improved by a mean 44%. Dyskinesias were ameliorated. Levodopa daily dose was reduced. Three patients required the implantation of the second electrode__.__ Unilateral DBS may be efficac