Urodele amphibians are nearly the only adult vertebrates able to regenerate their missing or amputated tail. An interesting aspect of this biological model lies in the ability of regenerates to differentiate the spinal cord (SC), the vertebral cartilage, and muscles. The main questions addressed in
Dedifferentiation and the role of sall4 in reprogramming and patterning during amphibian limb regeneration
โ Scribed by Anton W. Neff; Michael W. King; Anthony L. Mescher
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 254 KB
- Volume
- 240
- Category
- Article
- ISSN
- 1058-8388
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Background: Following amputation of a newt limb, tissues at the amputation site undergo histolysis to give rise to a growth bud, or blastema, but they also provide a base on which the regenerate is constructed. Studies suggest that dermal tissues may differentially resist histolysis. Methods and Re
## Abstract Left front limbs of adult male newts were given 2000r of Xโirradiation at least four weeks prior to amputation of both forelimbs. Internal stump tissues were evaluated for the ability to incorporate ^3^Hโthymidine and accumulate colchicineโblocked mitotic figures. In otherwise uninjured