Dedifferentiated chondrosarcoma with t(9;22)(q34;q 11-12)

✍ Scribed by Dr. Maija Tarkkanen; Sakari Knuutila; Tom Wiklund; Martti Virolainen; Inkeri Elomaa

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 361 KB
• Volume: 9
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870090210

✦ Synopsis

Translocation t(9;22)(q22-3 I ;q I I -12) is associated with the rnyxoid variant of chondrosarcorna We present here a report of a patient with a dedifferentiated grade IV chondrosarcorna, which originated from the iliac bone and contained areas of grade I chondrosarcorna There was no evidence of rnyxoid differentiation. The tumor had the karyotype 46,X,-X,t(9;22)(q=q I I -12). + rnar[5]/52-6 I ,x?,2-3drnin,inc[9]/46,XX[2]. It is possible that the different breakpoints in the t(9;22) may reflect different histopathologic subgroups of chondrosarcorna. Genes Chrom Cancer 9: 136-140 (I 994). 0 I994 Wiiey-Liss, inc.