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Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

✍ Scribed by Mohlopheni J. Marakalala; Ann M. Kerrigan; Gordon D. Brown

Book ID
106015604
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
334 KB
Volume
22
Category
Article
ISSN
0938-8990

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✦ Synopsis

The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.

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## Abstract ## BACKGROUND In addition to possessing many physiologic functions, human growth hormone‐1 (GH1) has been shown in recent in vitro and in vivo experiments to induce malignant disease, including breast carcinoma. The authors investigated the association of breast carcinoma with genetic