Decreases of plasma tryptophan concentrations following restricted feeding do not decrease serotonin and its metabolite in rat brain
✍ Scribed by Haleem, Darakhshan J.
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 385 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0027-769X
No coin nor oath required. For personal study only.
✦ Synopsis
Rats trained on a restricted feeding (RF) schedule of 4 h/day were killed before (starved) and after (fed) the presentation of food to compare hepatic and brain tryptophan metabolism with feeding (FF) controls. The R F rats exhibited greater holo-tryptophan pyrrolase activity in the liver than FF controls. Holoenzyme activity of starved rats was greater than fed animals. Plasma levels of tryptophan highcr in the FF rats were comparable in the starved and fed groups of R F rats. Plasma levels of glucose comparable in the F F and R F fed rats were smaller in the starved animals. Brain levels of tryptophan comparable in the R F fed rats and FF controls werc smaller in R F starved rats. Brain concentrations of serotonin (5-hydroxytryptamine) and its metabolite 5-hydroxyindoleacetic acid comparable in the R F starved rats and FF controls were higher in the R F fed rats. Possible implication of the findings in the pathogenesis of food deprivation/starvation related disease, anorexia nervosa Is discussed.
Zusammenfassung
Abnahme der Plasma-Tryptophankonzcntration nach begrenzter Fiittcrung fiihrt nicht zur Abnahme von Serotonin und dessen Mctabolit im Rattengehirn.