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Decreased striatal dopamine transporter binding in a patient with extrapontine myelinolysis

✍ Scribed by Joong-Seok Kim; Kwang-Soo Lee; Si-Ryung Han; Yong-An Chung

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
117 KB
Volume
18
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We describe the case of a 61‐year‐old woman who developed extrapontine myelinolysis (EPM) with parkinsonism. Decreased striatal dopamine transporter binding assessed by [^123^I]N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(4‐chlorophenyl) tropane and single photon emission computed tomography ([^123^I]IPT) SPECT) were observed in the patient, suggesting that osmotic injury causes the demyelination of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of EPM with parkinsonism.

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