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Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide

✍ Scribed by Victor Appay; Daniel E. Speiser; Nathalie Rufer; Severine Reynard; Catherine Barbey; Jean-Charles Cerottini; Serge Leyvraz; Clemencia Pinilla; Pedro Romero


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
454 KB
Volume
36
Category
Article
ISSN
0014-2980

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## Abstract MHC class I tetramers containing peptide epitopes are sensitive tools for detecting antigen‐specific CD8^+^ T‐cell responses. We demonstrate here that binding of HLA‐A2 tetramers to CD8^+^ T cells specific for the melanoma‐associated antigen Melan‐A/MART‐1 can be fine‐tuned by altering