Depleted skeletal muscle mitochondrial D
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Steen B. Haugaard; Ove Andersen; Steen B. Pedersen; Flemming Dela; Bjørn Richels
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Article
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2005
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John Wiley and Sons
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English
⚖ 120 KB
## Abstract The nucleoside reverse transcriptase inhibitors (NRTIs), especially stavudine, may deplete mitochondrial (mt) DNA in human tissues by inhibiting the mitochondrial polymerase gamma, a setting, which is associated with hyperlactatemia. The aim of the present study was to examine whether h