Human diploid fibroblasts (HDF) were used to study aging-related changes in the pro1 iferative response to platelet-derived growth factor (PDGF), epidermal growth factor (ELF), and insulin-like growth factor I (IGF-I, somatomedin-C) in serumfree, chemically defined culture medium. Cell cycle kinetic
โฆ LIBER โฆ
Decreased response to epidermal growth factor during cellular senescence in cultured human microvascular endothelial cells
โ Scribed by Takao Matsuda; Kazuki Okamura; Yasufumi Sato; Akio Morimoto; Mayumi Ono; Kimitoshi Kohno; Michihiko Kuwano
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 935 KB
- Volume
- 150
- Category
- Article
- ISSN
- 0021-9541
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โฆ Synopsis
We have previously demonstrated that epidermal growth factor (EGF) induces cell migration, tissue-type plasminogen activator synthesis, as well as tubular forma-
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## Abstract Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signa