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Decreased response to epidermal growth factor during cellular senescence in cultured human microvascular endothelial cells

โœ Scribed by Takao Matsuda; Kazuki Okamura; Yasufumi Sato; Akio Morimoto; Mayumi Ono; Kimitoshi Kohno; Michihiko Kuwano


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
935 KB
Volume
150
Category
Article
ISSN
0021-9541

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โœฆ Synopsis


We have previously demonstrated that epidermal growth factor (EGF) induces cell migration, tissue-type plasminogen activator synthesis, as well as tubular forma-


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## Abstract Growth factor receptors of the tyrosine kinase family regulate proliferation of a variety of cell types. In some human cancers, the epidermal growth factor receptor (EGFR) and its ligands often are overexpressed, leading to both constitutive and autocrine activation. Intracellular signa