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Decreased Prostaglandin E2 Production by Inflammatory Cytokine and Lower Expression of EP2 Receptor Result in Increased Collagen Synthesis in Keloid Fibroblasts

✍ Scribed by Hayashi, Toshihiko; Nishihira, Jun; Koyama, Yoshikazu; Sasaki, Satoru; Yamamoto, Yuhei

Book ID: 110049305
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 179 KB
Volume: 126
Category: Article
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5700227

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In a recent communication, we demonstrated that prostaglandin E 2 (PGE 2 ) lowers basal while it ablates interleukin-1␤( (IL-1␤) and transforming growth factor-␤ (TGF␤) upregulated lysyl oxidase (LO) mRNA levels. Correspondingly, PGE 2 increases cyclooxygenase-1 (COX1) mRNA in diploid, human embryo