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Decreased NURR1 gene expression in patients with Parkinson's disease

✍ Scribed by Weidong Le; Tianhong Pan; Maosheng Huang; Pingyi Xu; Wenjie Xie; Wen Zhu; Xiong Zhang; Hao Deng; Joseph Jankovic

Book ID
119302737
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
203 KB
Volume
273
Category
Article
ISSN
0022-510X

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## Abstract We performed sequence analysis of all the exons and exon–intron boundaries in familial and young‐onset Parkinson's disease (PD) in an Asian cohort. None of the patients carried any pathogenic mutations in the Nurr1 gene. We demonstrated a 5 to 10% prevalence of the intron 7 +33 Cβ†’T vari