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Decreased neutrophils and megakaryocytes in anemic mice of genotype W/Wv

✍ Scribed by Paul A. Chervenick; Dane R. Boggs

Book ID
102308375
Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
495 KB
Volume
73
Category
Article
ISSN
0021-9541

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✦ Synopsis

The concentration of neutrophils and megakaryocytes was determined in the marrow of anemic mice of genotype W/Wu and their normal (+/+) litter mates. In all groups studied, the humerus of W/Ww mice contained significantly less neutrophils and megakaryocytes than did normal animals. Blood neutrophil concentration was less in all groups of W/Wv mice but in only one group which was the youngest group studied, did this value differ significantly from normal.

The blood and marrow neutrophil response to endotoxin was similar in W/Wa and "+/+" animals. This suggests that the neutrophilic system of W/Wv mice responds to this stimulus in a relatively normal manner, much as their erythroid system responds to hypoxia, and androgens.

Considerable knowledge has been accumulated regarding the macrocytic anemia of mice with substitutions of the W locus.

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